What about investigations related to cannabis dosing?

A little over a decade later, the Institute of Medicine (IOM) ran an investigation into the physiological risks of cannabis use and its team came to the following conclusions: 

“Marijuana is not a completely benign substance. It is a powerful drug with a variety of effects. However, except for the harms associated with smoking, the adverse effects of marijuana use are within the range of effects tolerated for other medications.”

It wasn’t then until 1995 when the World Health Organization (WHO) prepared a review of the long-term effects of cannabis use, stating that consumption of the plant in moderate amounts was not to be feared; that the plant was incredibly safe for human use. The WHO’s review compared the use of cannabis with other therapeutically active substances, stating that cannabis benefits from a lack of overdose risk. The report read:

“There are no recorded cases of overdose fatalities attributed to cannabis”.

Can you overdose on cannabis?

The short answer to this question is “no”. While the appropriate cannabis dose or weed dosage may be different for each individual, the average-sized human would have to consume at least 1,500 pounds of cannabis within the space of 15 minutes in order to overdose on the plant, which is, without doubt, simply impossible to do.

Interestingly enough, there’s a system that exists for the measuring of a lethal dose of any drug or drug-like substance. This system is called LD50 and it’s considered to be fairly accurate for 50% of the population. According to this system, cannabis is widely considered to be one of the safest substances known to us on the planet.

Dr. Lester Grinspoon, a psychiatry professor at Harvard Medical School, wrote the following text about the unlikely possibility of a cannabis overdose for the Journal of the American Medical Association in 1995. His statement read:

“One of marihuana’s greatest advantages as a medicine is its remarkable safety. It has little effect on major physiological functions. There is no known case of a lethal overdose; on the basis of animal models, the ratio of lethal to effective dose is estimated as 40,000 to 1. By comparison, the ratio is between 3 and 50 to 1 for secobarbital and between 4 and 10 to 1 for ethanol [alcohol].”


“Marihuana is also far less addictive and far less subject to abuse than many drugs now used as muscle relaxants, hypnotics, and analgesics. The chief legitimate concern is the effect of smoking on the lungs. Cannabis smoke carries even more tars and other particulate matter than tobacco smoke. But the amount smoked is much less, especially in medical use, and once marihuana is an openly recognized medicine, solutions may be found; ultimately, a technology for the inhalation of cannabinoid vapors could be developed.”

Cannabis dosing and modern technology

So, whether you’re trying to establish the perfect CBD oil dosage, medical cannabis dosage, CBD oil for pain dosage, edible canabis dosage, or how much mg of THC to get high, it’s highly unlikely that you will run the risk of an overdose as you continue to experiment in order to find your body’s sweet spot.

The technology that Dr. Grinspoon alluded to is now included as part of the package across a wide range of desktop and pocket vaporizers. Even when evaluating the health of chronic cannabis consumers, the LD50 technology has shown that inhaling cannabis doesn’t increase the risk of cancer or other related diseases by any means. 

Even so, experts are unwilling to describe cannabis as being completely “harmless.” The physiological effects, including dilation of blood vessels and rapid heart rate, that we experience from cannabis use can be dangerous, in very limited cases, particularly when cardiac conditions are added to the context. In Dr. Grinspoon’s own words:

“The greatest danger in medical use of marihuana is its illegality, which imposes much anxiety and expense on suffering people, forces them to bargain with illicit drug dealers, and exposes them to the threat of criminal prosecution.”

How to find the right cannabis dosage for you

Many consumers opt for micro-dosing, starting with a low dose and gradually incrementing over a period of a few days in order to find the exact dosage of medical marijuana that helps manage any given condition or ailment. 

Some consumers make use of a cannabis edible dosage calculator, particularly because edibles have a tendency to hit the body harder than other consumption types and because they can help to work out how long an edible takes to kick in.

If you need help with cannabis dosing, feel free to contact our team directly. We’re here to help.